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Research

Fusheng Tang, Assistant Professor, Department of Biology

The Tang laboratory studies the contribution of intracellular sterol transport to life span extension. The eukaryotic cell is divided into many membrane-bound organelles. Each organelle membrane has its unique sterol content and composition. Cells synthesize sterols in the endoplasmic reticulum or uptake sterols from the environment. How do cells transport sterols from their origins to destination membranes? In Tang lab, we are using the membranes of yeast vacuoles and mammalian lysosomes as model destination membranes to address this question. Currently, we are studying the family of oxysterol-binding proteins that are implicated in sterol transport among membranes with genetics, cell biology, and bioinformatics approaches. Since vacuoles and lysosomes are critical for life span extension, exploring how cells maintain the sterol homeostasis of these membranes will fundamentally advance aging studies. Key words: aging, sterol, membrane, transport

Updated 5.20.2010